By Janet Gulland, Contributing Writer
Twice daily supplementation with δ-tocotrienol, one of the eight isoforms of vitamin E, produced marked reductions of body mass index, triglyceride levels, markers of inflammation, alanine transaminase (ALT) and aspartate transaminase (AST) in a cohort of overweight patients with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).
The data, from a 71-patient placebo-controlled study, suggest that δ-tocotrienol has a great potential role to play in the management of these increasingly common and co-occurring conditions.
Dr. Muhammad Amjad Pervez and colleagues at the National University of Medical Sciences, Islamabad, Pakistan, randomized the 71 patients—all of whom were overweight or obese, with the characteristics of metabolic syndrome, and ultrasound-confirmed NAFLD—to twice-daily treatment with either 300 mg δ-tocotrienol (total of 600 mg/day) or identically matched placebo capsules.
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